“I’ve always felt very secure and confident with myself in knowing what I could do and what I could not. And so it’s not something that interests me,” the 63-year-old former talk show host told InStyle Editor-in-Chief Laura Brown in the cover story for the March Fashion Issue. “I don’t have the DNA for it.”

But interest in Winfrey’s possible presidential run swelled following her rousing Cecil B. DeMille Award acceptance speech at the 2018 Golden Globe Awards, where she assured sexual predators that their “time is up.”

“I want all the girls watching to know a new day is on the horizon,” she said. “And when that new day finally dawns, it will be because of a lot of magnificent women, many of whom are right here in this room tonight, and some pretty phenomenal men, fighting hard to make sure they are the leaders to take us to the time where nobody has to say ‘me too’ again.”

Following the uprise in speculation over Winfrey’s potential political plans, President Donald Trump addressed the buzz, offering rare praise for a potential rival while also boasting that he would defeat her.

Opening a bipartisan meeting on immigration reform, Trump told reporters in the Cabinet Room: “Yeah, I’ll beat Oprah — Oprah would be a lot of fun. I know her very well.”

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“I like Oprah,” he said. “I don’t think she’s going to run.”

Winfrey taped the podcast in New York City on Wednesday at the historic Apollo Theater. The evening focused around one-on-one conversations with thought leaders and modern-day influencers as they discussed the current climate in our culture.

The mogul also sat down with Salma Hayek, Stephen Colbert, Trevor Noah, Jordan Peele and Yara Shahidi.

The special will air on OWN Tuesday, February 27 at 10 p.m.

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